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Growth and apoptosis Ex-4 significantly improves the survival of rat cortical neurons under oxygen/glucose deprivation (OGD) conditions through reduced apoptosis rates, increased expression of glucose-regulated protein 78, and decreased levels of C/EBP-homologous protein, indicating the role of Ex-4 in modulating unfolded protein response for protecting neurons from ischemic damage [56]

By inhibiting cysteine importation, we were able to interrupt melatonin-induced GSH accumulation and found that in doing so we also suppressed the anti-inflammatory effects of melatonin treatment

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