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In vitro studies, although useful for clarifying molecular pathways as NF-B suppression, antioxidant enzyme overexpression, sometimes employ elevated, non-physiological concentrations of extracts and may fail to correctly simulate the complex context of the human eye

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There is a possibility that the imbalance of gut microbiota can damage the intestinal epithelium before UC develops, which can directly affect the intestinal permeability, so that excessive microorganisms enter the intestinal tissue and induce infection, which may lead to UC