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Our computational framework results 66 are consistent with recent clinical evidence from the phase 3 EVOKE and EVOKE+ trials (NCT04777396, NCT04777409), which are the first large-scale, randomized, double-blind, placebo-controlled studies designed to evaluate the disease-modifying potential of semaglutide in early-stage symptomatic AD 67,68

At 24 weeks, the mean percentage decrease in weight ranged from 7.2% to 17.5% across retatrutide groups versus 1.6% with placebo

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Future studies should measure multiple nutrients simultaneously and use multivariate models to isolate the independent effects of individual nutrients