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Although GLP-1 RAs have demonstrated efficacy even without structured behavioral support, their broader therapeutic potentialparticularly regarding long-term behavior change, psychological stabilization, and sustained weight lossmay be most effectively realized when embedded within a biopsychosocial framework
2023;9:e14961
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Initial results from that trial were met with shrugs when the drug failed to generate as much weight loss as injectable semaglutide, in data announced in early August
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