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These include some heartburn medicines, including esomeprazole (Nexium), famotidine (Pepcid AC), lansoprazole (Prevacid), omeprazole (Prilosec OTC), pantoprazole (Protonix), rabeprazole (Aciphex), as well as some diabetes, gout, and chemotherapy drugs

Its particularly popular among athletes and individuals recovering from injuries

The diagnosis of 5-oxoprolinase deficiency is established by: Low activity of 5-oxoprolinase in nucleated cells such as leukocytes or cultured skin fibroblasts (5-oxoprolinase is not present in erythrocytes)

ROS are products of normal physiological activities and are a general term for a class of chemically active molecules and ions with high oxidative activity, which play important roles in cell signaling and tissue homeostasis ( 2 - ), peroxides (H 2 O 2 and LOOH), and free radicals (HO and LO)