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They work by speeding up the breakdown of cholesterol in the digestive system

164,165 Additionally, research involving humans appears to corroborate these results, indicating that GLP-1 RAs reduce inflammatory markers, with clinical trials showing decreases in TNF- and IL-6 levels among individuals with T2D

Endogenously, GLP-1 is secreted by intestinal L cells in response to food, and has multiple roles: enhancing insulin secretion (in a glucose-dependent way), reducing glucagon secretion, slowing gastric emptying, increasing feelings of fullness/satiety, and improving glucose disposal in peripheral tissues

You can read study designs, enrollment criteria, and official results summaries