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In obese mouse models, liraglutide improved insulin sensitivity in visceral adipose tissue, which was associated with reduced endoplasmic reticulum stress and increased Akt phosphorylation following insulin stimulation ( FIGURE 3 Both peripherally secreted GLP-1 and pharmacologic GLP-1RAs can cross the bloodbrain barrier (BBB) or interact with circumventricular organs, suggesting that peripheral administration is sufficient to reach CNS targets

Macroalbuminuria occurred less (2.2%) in exenatide group compared to placebo group (2.5%) [HR 0.87 (95% CI: 0.701.07)]

Animal studies have demonstrated that GLP-1 receptors are present in the mesolimbic reward pathway, including the ventral tegmental area and nucleus accumbensbrain regions implicated in food reward and addictive behaviors