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According to the experimental evidence that apoptosis is the main mechanism for neuronal death in neurodegenerative diseases and that all the investigated proteins are important targets for treating AD-related abnormalities, our results support the role of TIR as an intriguing therapeutic possibility for the treatment of neurodegenerative disorders beyond its hypoglycemic effects

One 2022 pilot study (n = 24) found modest improvement in skin brightness (+8 % L* value) after eight weeks of topical application