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Routine administration during pregnancy is generally discouraged unless potential benefits clearly outweigh theoretical risks

Ethics approval for animal experimentation All experiments were reviewed, approved and conducted in an Association for Assessment and Accreditation of Laboratory Care International (AAALACi)-approved animal facility, the Sanofi Genzyme Institutional Animal Care and Use Committee

Some of the biomarkers associated with aging include increased SA--Gal activity, elevated levels of p16INK4a and p21CIP1 (cell-cycle inhibitors), and SASP, a phenotype composed of cytokines, chemokines, metalloproteinases, growth factors, reactive metabolites, and extracellular vesicles

Potential value in the treatment of liver cancer (basic research stage) Additionally, -adrenergic receptor antagonists show promise in liver tumor treatment