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Erdman J, Oria M, Pillsbury L, editors

Although de novo polyamine synthesis from ornithine represents the major source of intracellular polyamines, transport of extracellular polyamines into cells is accomplished via the SLC45A4 encoded transporter which is a member of the glycoside-pentoside-hexuronide cation symporter family of transporters

The significance of this paper is not only to compare the three routes of administration but also to evaluate them and determine which route is the best to administrate the drug