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In hypertension, GLP-1 attenuates the excitability of carotid body cells diminishing sympathetic activation, augments renal blood flow to promote natriuresis and diuresis as well as facilitates generation of nitric oxide in vascular smooth muscle cells

In Boston, Chief Financial Officer Ashley Groffenberger wrote to the City Council March 16 that covering GLP-1 drugs for weight loss cost the city an estimated $31.6 million in fiscal 2026, expected to rise to $47.4 million in fiscal 2027, which starts July 1

Adhesion molecules of the endothelial cells make contacts with monocytes which later invade the vascular wall and differentiate into macrophages

If replicated in larger prospective trials, that magnitude of difference would carry significant clinical implications