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The basic idea is that fecal matter builds up in the colon and leads to autointoxication, which is "an ancient theory based on the belief that intestinal waste products can poison the body and are a major contributor to many, if not all, diseases," according to a report in the Journal of Clinical Gastroenterology

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If that substance contains contaminants, undeclared fillers, or incorrectly synthesized molecules, you're not just risking skewed datayou're introducing a host of confounding variables that can render your entire study useless

Recognizing these translational gaps is essential for the development of more predictive preclinical systems, such as humanized mouse models and integrated organoidimmune coculture platforms, which may bridge the gap between experimental efficacy and real-world applicability