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Sham-operated rats underwent the same surgical procedure except for the MCA occlusion

In such cases, your provider may review your treatment plan and suggest adjustments, such as modifying the dose or offering supportive strategies to improve tolerance and comfort

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The SURMOUNT-1 trial specifically noted that participants with a BMI of 35 or higher who received the 15mg tirzepatide dose lost an average of 26.5% of their body weight, substantially higher than the overall trial average