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Microscopically, spindle-shaped and plump epithelioid cells appear in intertwined fascicles or nests (50)

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Lipoic acid might be able to increase glutathione synthesis in aged rats by up-regulating the expression of -glutamylcysteine ligase (-GCL), the rate-limiting enzyme in glutathione synthesis (31), and by increasing cellular uptake of cysteine, an amino acid required for glutathione synthesis (32)

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