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Evidence of direct depletion: Weak Mechanistic plausibility via reduced intake: Moderate Symptoms of B12 Deficiency Neuropathy Fatigue Brain fog Macrocytic anaemia Persistent fatigue during GLP-1 therapy can have multiple causes, including caloric restriction and micronutrient shifts

Subsequent gene-expression analyses cited in the review identified GHK-Cu as modulating expression of approximately one-third of human genes, with a pattern consistent with reversal of age-related transcriptomic shifts