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Elife (2022) 11:e74391

W., Sackler R

however, if SGLT2is are not tolerated or are contraindicated, or if eGFR is less than adequate, a GLP-1RA with proven CV benefit can be added ( In recent guidelines on diabetes, prediabetes, and CVD from the European Society of Cardiology, in collaboration with the EASD, GLP-1RAs with proven CV benefit (liraglutide, semaglutide, and dulaglutide) are recommended as an add-on therapy to metformin ( Mechanisms for the Cardiovascular Benefits of GLP-1RAS Different mechanisms have been proposed to explain the CV benefits elicited by some GLP-1RAs ( 1c , body weight, and systolic blood pressure were also those associated with CV-event reduction

In a clinical trial in pediatric patients aged 12 years and older with normal baseline heart rate, more patients treated with WEGOVY injection compared to placebo had maximum changes in heart rate of 20 bpm or more (54% versus 39%) [see Adverse Reactions (6.1)]