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FIGURE 17 5 Conclusion The expression of GLP-1R in tissues other than the pancreas, such as the brain, endocrine tissues, heart muscle, kidneys, lungs, muscle, and vascular tissues, as well as the proximal digestive and gastrointestinal tract, indicates that GLP-1 has a multifaceted regulatory role beyond glucose homeostasis mediated by insulin release

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In the worst cases, gastroparesis can make it very difficult to eat or drink anything at all, potentially causing dehydration or malnutrition

This is to minimize potential side effects like nausea, vomiting, constipation, or diarrhea, which can be quite intense for some