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Physical discomfort and social limitations from constipation symptoms, combined with low mood and anhedonia from depressive symptoms, result in severe functional impairment

Extracellular Acidification Lactate, the final product of glycolysis, is released from cells together with H + ions by means of monocarboxylate transporters and hydrogen ion pumps, and the excess carbon dioxide produced in the process of mitochondrial metabolism diffuses into the extracellular space and is then converted into H + and HCO3- by carbonic anhydrase (265)

2008;294:E84652

The diagnosis usually involves the following: clinical findings, the finding of 5-oxoprolinuria, low levels of glutathione, low activity of glutathione synthetase, and mutation analysis of the glutathione synthetase gene