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Tesofensine, conversely, works in the brain as a triple monoamine reuptake inhibitor, affecting serotonin, norepinephrine, and dopamine to suppress appetite

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After being fed HFD for a total of 16-weeks (an appropriate rodent model of DIO and comparable to human obesity [21]) and reaching pre-arrival body weights (~38g), mice were randomized into balanced control and treatment cohorts (n=9/cohort), with similar group average body weight and standard deviation

Robert Cox and Sam Jacob of the Histopathology Research Laboratory at Shriners Hospital for Children, Galveston for their support in histological processing and light microscopic analysis of the EWAT tissue samples (grant #84060, PI: Dr