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Notably, LMF-induced calcium influx through voltage-gated channels may act as a trigger for EV biogenesis and cargo sorting, as calcium signaling is known to regulate vesicle trafficking and the matrix metalloproteinase (MMP) activation [59-61] [Figure 1]

Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases

This fundamental difference in mechanism is why peptides have generated such interest despite the limitations of current evidence

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