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While both are studied for healing, BPC 157 is often associated with direct structural repair and angiogenesis

Breaks make sense for users experiencing treatment plateau where benefits cease increasing despite continued application suggesting diminishing returns from ongoing use, comfortable with some benefit decline during off periods accepting fluctuation in skin quality, budget-conscious seeking to minimize annual treatment costs through intermittent purchasing, philosophically preferring avoiding indefinite dependency on any skincare product, planning life changes incompatible with consistent application (extended travel, relocation, financial shifts), and wanting to assess whether improvements prove durable or require continuous maintenance before committing to indefinite treatment

Regional and cell-type differences are substantial, and observed changes may involve synthesis, transport, mitochondrial balance, or neuroinflammation (Aoyama, 2021)