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While immortalized cell lines like Caco-2 and T84 cells have limitations in representing individual-specific responses and complex behaviors due to their transformed nature, primary intestinal cells derived directly from human donors or patients offer several advantages, as previously mentioned

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Cui Y, Zhang Y, Zhao X, Shao L, Liu G, Sun C, Xu R, Zhang Z (2021) ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation