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Although there is no cure for RA, early diagnosis and proper treatment can usually prevent joint destruction and other complications

The subject headings and text keywords included those related to the population of interest (i.e., IC, BPS), intervention (relevant treatments such as medication, instillation, intravesical injection, physical therapy and/or others), comparison (placebo or control), and outcomes of treatments: 1) individual symptoms (pain, frequency, urgency and nocturia), 2) structured questionnaires (interstitial cystitis problem index [ICPI], interstitial cystitis symptom index [ICSI], pelvic pain urgency frequency symptom scale [PUF] and functional bladder volume [FBV])