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Some short-term studies in healthy older adults have been done with GHRH analogs like sermorelin or other secretagogues, and while they sometimes show increases in lean mass or decreases in fat mass, the improvements are modest and can be accompanied by side effects (e.g

Li Y, Perry T, Kindy MS, Harvey BK, Tweedie D, Holloway HW, et al

In experimental models, researchers often measure oxygen consumption, substrate oxidation patterns, metabolic biomarkers, and energy balance parameters to evaluate how receptor activation influences energy utilization across tissues

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