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The core direction of future research should focus on directly verifying the causal relationship between local joint ferroptosis and gut microbiota dysbiosis through germ-free OA mouse models, fecal microbiota transplantation experiments, or conditional knockout models of key genes for chondrocyte-specific ferroptosis (such as GPX4 and ACSL4)

Future directions include biomarker-driven personalization of lifestyle interventions, gut microbiota profiling, and incorporation of exercise and diet into standard oncologic care pathways

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