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DPP-4 inhibitors are increasingly replacing sulfonylureas as insulinotropic agents, but they can frequently also be a good therapeutic alternative to other treatment options such as glitazones or glucosidase inhibitors
What needs to be balanced against this is the reported association between GLP-1 receptor agonist therapy and pancreatitis, pancreatic hyperplasia and pancreatic neoplasia [71]
High quality human clinical trials studying the combination are limited, and people with diabetes or kidney disease should be cautious and consult a clinician before starting
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