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Interestingly, GSTO1 was identified as one of the potential cellular targets of piperlongumine, an electrophilic compound exerting selective cytotoxicity against cancer cells through an oxidative cell death mechanism (Supplementary Table 25) 37

Savage-Dunn C, Yu L, Gill K, Awan M, Fernando T (2011) Non-stringent tissue-source requirements for BMP ligand expression in regulation of body size in Caenorhabditis elegans

The classical forms of the disease are more severe and are likely to be diagnosed early in life, as opposed to the non-classical form, which may be confused with PCOS due to overlapping symptoms, including female infertility