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Academic Press, New York

Several factors amplify this: Reduced protein intake when eating 1,000-1,500 calories per day, most people don't hit protein targets Metabolic adaptation the body downregulates energy expenditure, slowing BMR Reduced activity many patients become less active as appetite suppression also suppresses drive Blunted anabolic signaling GLP-1 pathways don't directly stimulate muscle protein synthesis Strategic peptide stacking addresses multiple points in this cascade simultaneously