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A serotonin 5-HT 2A receptor antagonist was shown to reduce neuronal proliferation, and chronic administration of a 5-HT 1A receptor agonist increased neuronal proliferation (Jha et al., 2008)

Pregnant Women : Before starting treatment with Topamax or Qsymia, tell your doctor if you are pregnant or planning a pregnancy in the near future, as phentermine and topiramate can cause serious congenital disabilities in the unborn baby, including cleft lip and cleft palate