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Conclusion This novel study in youth with type 2 diabetes demonstrated that short-term metformin improved postprandial blood glucose levels and was associated with modest increases in incretin concentrations in the absence of changes in rates of glucose production and gluconeogenesis

Ethics declarations Ethics approval and consent to participate All animal experiments were conducted after approval from the Institutional Animal Care and Use Committee of the Tongji Medical College, Huazhong University of Science and Technology, and all procedures were in compliance with the relevant guidelines and regulations of the Chinese Council on Animal Care

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