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As acyl-CoAs are not excreted from cells and are thus not possible to measure directly in plasma or excreta, identification of acyl-CoA dependent metabolites such as amino acid conjugates, acyl carnitines, and metabolites formed through -oxidation can provide insights into acyl-CoA formation and the possible roles in formation of reactive metabolites

A recent study showed that HIF-2-mediated overexpression of SLC1A5 variants in mitochondria plays an essential role in glutamine metabolism in pancreatic cancer cells by inducing chemotherapy resistance 82

Peptide therapies may not be FDA-approved for all uses and may not be appropriate for every patient

Nikseresht et al., 2019)