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Specifically, we stated that we are considering the effectiveness of the current requirements for determining an ACO's participation options, finalized with the December 2018 final rule, and modified through subsequent rulemaking, including the CY 2023 PFS final rule, in achieving a balance between encouraging transition to two-sided risk and a concern that requiring ACOs to take on too much downside risk too quickly may disincentivize program participation

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Liposomal Glutathione is basically glutathione encapsulated in tiny spherical vesicles (liposomes) made with lipids (fatty compounds)

Liu S, Zhang L, Li S