If you experience intolerable side effects on one formulation or dose schedule, discussing alternative agents, slower titration, or a different administration route with your provider is a standard clinical approachnot a failure of the medication itself
Someone with a history of pancreatitis, established gallbladder disease, advanced kidney impairment, or diabetic retinopathy is not automatically disqualified by the label but a prescriber has to decide whether the benefit justifies the risk for that specific person, and what monitoring the decision requires
The right dosage is the lowest one that achieves the clinical goal you and your prescriber set
Mass spectrometric detection was carried out in ESI-SIM mode, monitoring the ions [M+3H] at m/z 1372 and [M+4H] at m/z 1029 *LOD was determined for this combination of instrument, method, and analyte, and it can vary from one laboratory to another even when the same general type of analysis is being performed