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DEgidio F, Castelli V, Lombardozzi G, et al

Tesamorelin elevates IGF-1, and this elevation must remain within normal physiological range (roughly 100 to 300 ng/mL depending on age)

Table 1 Preclinical studies exploring the neuroprotective effects of GLP-1R agonists

Three pilot studies with very small sample sizes, a Phase II trial whose results remain unpublished, and a regulatory record that reflects the FDA's own assessment that sufficient human safety data do not exist that is the complete ledger as of 2025