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Microglia mediate host defense against infectious pathogens, harmful self-proteins such as A, aggregated -synuclein, mutant or oxidized superoxide dismutase, mutant huntingtin or prions, as well as primary or metastatic CNS tumors (Hickman et al., 2018)

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Excessive acetyl-CoA production in the process of -oxidation inhibits the tricarboxylic acid (TCA) cycle, leading to mitochondria stress in hepatocytes [9, 10]