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Another level of complexity is added by the introduction of international units (IU)

Front Endocrinol (Lausanne) 2012;3:141

When the medication enters subcutaneous tissue, fluid shifts occur around the injection site as your body works to equilibrate concentrations, triggering transient inflammation and the characteristic burning sensation

Some researchers theorize that the GIP component may actually help moderate some of the harsher GI effects of GLP-1 activation, which could partially explain why retatrutide compared to other agents does not always show proportionally worse GI profiles despite having three active mechanisms