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A direct consequence of this is that the difference in efficacy between retatrutide and tirzepatide (approximately -7,8 points) must be weighed against this difference in tolerability and a discontinuation rate two to three times higher

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In preclinical models it accelerates mucosal tissue repair, supports intestinal lining integrity, reduces markers of intestinal permeability, and promotes angiogenesis in gastrointestinal tissue

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