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Lowering peripheral insulin level via using other antidiabetic drugs is feasible, but therapies targeting insulin signal pathways still needs a long way to go at present

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When evaluated by imaging, the impact of metformin on steatosis was neutral, as it was on BMI, whereas it was associated with a significant reduction in serum aminotransferase levels (especially serum ALT) and an improvement in HbA1c levels [133]

In the five in vitro studies, although a decrease in the apoptosis rate of granulosa cells was observed at specific doses, it was not confirmed whether this effect could translate into an improvement in oocyte quality in vivo (Tsui et al., 2017