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Cagrilintide 2.4 mg Population: BMI 30, no diabetes Key Results (32 Weeks): Mean Weight Loss: 15.1% with CagriSema (combination) 9.8% with semaglutide 2.4 mg alone 7.7% with cagrilintide 2.4 mg alone Synergy Demonstrated: Combination produced 54% more weight loss than semaglutide alone, 96% more than cagrilintide alone 15% Weight Loss: 53% (CagriSema) vs

doi:10.1016/S0140-6736(23)01053-X PubMed: This trial evaluated retatrutide in 281 participants with type 2 diabetes, showing up to 16.94% weight loss and significant HbA1c reductions with favorable safety profile comparable to other GLP-1 based therapies

Nat Rev Drug Discovery