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Xu et al (116) found that liraglutide could mitigate cisplatin-induced nephrotoxicity by inhibiting nuclear-cytoplasmic translocation and release of high mobility group box 1 (HMGB1), reducing inflammatory cytokine levels and HMGB1 receptor expression

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a high-cardiovascular-risk kidney cohort showed a slower decline in kidney function and about a third less protein leak, which travels to a similar-risk body, not a healthy one. Lean and metabolically healthy: a safety read, not an efficacy target No long trial has tested tirzepatide in lean, metabolically healthy people