Moreover, high dopamine transporter (DAT) expression increases neuronal uptake of extracellular neurotoxins (e.g., MPP+, the active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)), which inhibit mitochondrial complex I, exacerbating ROS (O 2 - ) and DNA damage [73]
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Mdivi-1 effectively inhibited the expression of DRP1 and the mitophagy-related protein NIX in a dose-dependent manner (Supplementary Fig