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The hyperglycemia-related increased proximal tubular sodium reabsorption results in lower sodium levels at the level of the macula densa increasing GFR via inhibiting TGF, further augmenting the amount of filtered and reabsorbed sodium with increased ATP demands

When somebody loses weight whether thats with diet changes, an increase in physical activity, medication or bariatric surgery we know theres a reduction in fat mass, as well as a reduction in muscle mass

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