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This can lead to food remaining in the stomach for an extended period, causing uncomfortable fullness, nausea, bloating, and other digestive issues

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After a recent tirzepatide dose escalation, the patient developed severe vomiting, metabolic derangements, sepsis physiology, and later GI bleeding, requiring coordinated management by endocrinology, gastroenterology, and cardiology.As GLP-1 use expands, careful dose titration, awareness of overlapping syndromes, and early multidisciplinary involvement are essential