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[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Brkle A

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Why Opioids Backfire With Repeated Use With repeated exposure, the nervous system adapts to opioids, leading to: Tolerance , requiring higher doses for the same effect (33,35) Dependence , with withdrawal symptoms when doses wear off (35) Opioid-induced hyperalgesia , a paradoxical increase in pain sensitivity (33,36) Rather than calming pain long term, opioids can sensitize the nervous system, making everyday stimuli feel more painful (33,36)

Also, keep in mind that spermatogenesis, the process of sperm formation, takes about 2-3 months