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The observation that replacement of the N-terminal norleucine with GABA yielded a compound with superior antidementia activity indicated that an N-terminal -amino group was not required for activity

doi: 10.1002/adfm.202409707 193 ShengWLiaoSCaoSWeiYZhaoJYueYet al

513 Vedolizumab, a monoclonal antibody, is used primarily for the treatment of moderate-to-severe UC by targeting 47 integrins, blocking the homing pathway of colonic lymphocytes, and reducing the inflammatory response in the intestinal tract

Biomarker development: non-invasive markers predicting response to either drug could avoid the need for serial biopsies