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The serum ferritin content may also reflect the functional state of the liver, because this protein is stored in this organ

Also, individuals with COMT defects can be at higher risk for accumulating too much peroxynitrites which builds up in their bodies, causing stiffness and muscle pain or brain fog and cardiovascular problems

System Xc (a special cystine/glutamate transporter) exchanges intracellular glutamate for extracellular cystine in a 1:1 ratio ( transport may be inhibited by elevated extracellular glutamate levels

The health consequences of smoking50 years of progress: a report of the Surgeon General, 2014 [online], (2014)