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Pramlintide is a shorter-acting analog
Hooper AJ, Burnett JR, Watts GF
266,267 Excessive ROS levels lead to oxidative damage to DNA, proteins, and lipids, resulting in neuronal apoptosis and impaired nerve function
A Cochrane systematic review of randomized trials for melasma found combination therapy more effective than single agents (a Cochrane systematic review of randomized trials for melasma), and a study in Middle Eastern skin confirmed a tretinoin and hydroquinone combination was effective and tolerated in deeper skin tones (a study of a hydroquinone and tretinoin combination for melasma in deeper skin tones)
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