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In addition, we observed a reduction of KLF2 along with ERK5 degradation, which is a known downstream target gene of ERK5 (Fig

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While advances in bioinformatics and nanoformulations are enhancing their pharmacokinetic profiles and clinical applicability, challenges such as standardization, dosage optimization, and translational validation hinder their widespread clinical adoption

Indeed, the most frequent mutations in the SCL12A3 gene are those that result in lack of proper glycosylation of the NCC protein which prevents its trafficking to the membrane or interferes with its ability to transport Na + and Cl