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Furthermore, HIF-1 exerts profound effects on the recruitment, activation, and immunosuppressive functions of MDSCs

Across multiple independent cohorts (Table 1), UC is consistently associated with increased relative abundance of Proteobacteriaparticularly the Enterobacteriaceae alongside reduced levels of health-associated groups such as Bifidobacterium , Lachnospiraceae, and Verrucomicrobia (e.g., Akkermansia