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These pathogenic bacteria can colonize the gut by exploiting epithelial damage and activate TH1/TH17 immune responses through virulence factors, such as the type III secretion system (108)

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Third, intestinal K-cells and pancreatic islet cells, including -cells, may also contribute to pasireotide-induced hyperglycemia 17,21,42

Although the studies differed in design and overall quality, the research team evaluated their risk of bias using well-established assessment methods